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Neuroendocrine reflexes may also trigger GLP-1 secretion in addition to direct nutrient-induced stimulation of L-cell GLP-1 secretion [344]

An international multicenter trial is currently underway to validate the effects of GLP-1R activation in active IIH (NCT05347147)

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What the margin difference looks like in practice: Community sources describe the room-temperature-stored punctured vial as more likely to reach the boundary of preservative efficacy within the 28-day window still technically within the documented period, but with less safety margin